At a cost of more than $100 billion annually in the U.S., autoimmune diseases arise and persist due to the loss of immune tolerance to one’s own tissues. Immune tolerance is propagated through a variety of mechanisms, including suppression of self-reactive T effector cells and auto (self)-antigen presenting cells by T regulatory cells (Tregs). A numerical or functional deficit of Tregs curtails immune tolerance to self-tissues and innocuous external antigens, underpinning autoimmune and allergic diseases. Caladrius' technology to enhance autologous Treg number and function therefore leverages the native immune regulatory mechanisms, offering a path to true disease modification.
T Regulatory Cells (Tregs): Restoring immune balance and function
When Tregs function properly, only harmful foreign materials are attacked by T effector cells. In autoimmune disease, however, it is thought that deficient Treg activity and numbers permit the T effector cells to attack the body's own beneficial cells. Augmentation of number/potency of Tregs is intended to restore the immune system to its “native” state and reduce/eliminate autoimmune disease symptoms.