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Patients & Families

We keep the patient at the forefront of everything we do. Our core mission is to help patients living with chronic disease by providing access to novel regenerative therapies so they can live longer, better-quality and more functional lives.

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What is Regenerative Therapy?

Regenerative therapy is a generic term to describe the process of replacing or “regenerating” human cells, tissues or organs to restore or establish their intended function. Regenerative therapy techniques involve the placement of these reparative cells directly into the area of damage to stimulate the body’s own repair mechanisms to heal tissues or organs.

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Coronary Microvascular Dysfunction

Coronary microvascular dysfunction (CMD) is a disease that causes narrowing of the small blood vessels that are responsible for supplying oxygen-rich blood to the heart muscle. In CMD patients, there is no accompanying corresponding narrowing of the large vessels supplying blood to the heart. This decreases the amount of blood flow to the heart, leading to frequent chest pain (angina). CMD affects approximately 8.3 million people in the U.S., predominantly women; however, many people with CMD don’t even know they have it, as it is often unrecognized.

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Critical Limb Ischemia and Buerger’s Disease

Critical limb ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet, and legs) and has progressed to the point of severe pain and even skin ulcers or sores. CLI is a chronic condition that results in severe pain in the feet or toes, even while resting.

Buerger’s disease is a rare disease of the arteries and veins in the arms and legs. In Buerger’s disease — also called thromboangiitis obliterans — your blood vessels become inflamed, swell and can become blocked with blood clots. This eventually damages or destroys skin tissues and may lead to infection and gangrene (the death or decay of body tissues). (1) In some cases, amputation may be required. (2)

About Clinical Trials

Clinical trials are research studies that provide important information on the benefits, side effects and possible uses for medicines and therapies. Clinical trials evaluate new uses for currently available treatments or investigational treatments. Health regulatory agencies, like the U.S. Food and Drug Administration, review findings from clinical trials as part of the process to determine if an investigational therapy or new combination regimen should be approved for use.

The National Institutes of Health (NIH) maintains a database of key clinical trials being conducted in the United States. You can search the database to find trials that are enrolling as well as results from trials that have already completed.

Why should I participate in a clinical trial?

Participating in a clinical trial is a voluntary opportunity. It is important to consult with your doctor or other healthcare professionals about whether participating in a clinical trial is right for you. If you are interested in volunteering for a clinical trial, the trial staff will provide you with information about the study so you are aware of what is involved and determine if you are eligible to participate.

People elect to participate in clinical trials for many reasons, including:

  • There are no currently approved treatments for their condition;
  • They have not experienced improvements in their condition after using currently approved treatments;
  • They want access to a new type of treatment, even if it is not guaranteed to be as good as or better than available treatments; or
  • They want to contribute to the development of a new treatment for others with a similar condition.
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Clinical Trial Information

For more information about the basics of clinical trial participation and first hand experiences from volunteers, please visit NIH Clinical Research Trials and You website.